2, using standard mathematical descriptions of circulation, and with a focus on modeling purely aerobic exercise. That is, we only model blood flow, blood pressure, and O2 in several compartments, and yet the model captures the overall physiologic HR response during moderate exercise in young, fit adults. In standard models of aerobic cardiovascular control (27 ? ? ? –31) the neuroendocrine system controls peripheral vasodilation, minute ventilation, and cardiac output to maintain blood pressure and oxygen saturation within acceptable physiological limits.
Several features of these control systems allow substantial simplification of the model. Minute ventilation V ? E alone can tightly control arterial oxygenation [O2]a, so we assume [O2]a is maintained nearly constant (27). Moreover, peripheral resistance Rs is decreased during exercise and the decrease is determined by local metabolic control. The purpose of decreasing Rs in the arterioles is to increase blood flow and regional delivery of O2, glucose, and other substrates as needed. Because the venous oxygenation [O2]v serves as a good signal for oxygen consumption, we also assume that control of peripheral vascular resistance Rs is a function only of venous oxygenation [O2]v (31).
The c variables was constants
Combined with those models for blood circulation and oxygen consumption, we have the following physiological model: V a s = c a s ? P a s V v s = c v s ? P v s V a p = c a p ? P a p V v p = c v p ? P v p V t o t = V a s + V v s + V a p + V v p [ O 2 ] a = 0.2 Q l = c l ? H ? P v p Q r = c r ? H ? P v s F s = ( P a s ? Continue reading “Our very first-standards model is dependent on the circulatory routine diagram into the Fig”